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In a study of 1,685 patients treated with CPA, elevated liver enzymes were seen in 10% of patients at a dosage of 50 mg/day and in 20% of patients at a dosage of greater than 100 mg/day. [50] A study of 2,506 patients given 18–136 mg/day for less than 48 months per patient reported a rate of %. [51] [52] In a trial of 89 prostate cancer patients who received high-dose CPA for 4 years, there were elevated liver enzymes in % of the patients. [52] Yet another study of 105 patients found a hepatotoxicity rate of %, with serious hepatic injury occurring in %. [52] In 2002, it was reported that there were 18 case reports of CPA-associated hepatitis in the medical literature, with 6 of the cases resulting in death. [50] In addition, a review article cited a report of 96 instances of hepatotoxicity that were attributed to CPA, and 33 of these instances resulted in death. [50] Moreover, a 2014 review found that 15 cases specifically of CPA-induced fulminant (sudden-onset and severe) liver failure had been reported to date, with only one of these cases not resulting in death. [52] As such, the prognosis of CPA-induced liver failure is death. [52]

Boldenon jak dziala

boldenon jak dziala

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