3. There are no clear guidelines on maximal dosage. One study performed at the reproductive medicine department at UCLA in 1998, aimed to assess the effect of supplementation with larger oral dose (100mg) of DHEA in both women and men. After 6 months, prolonged DHEA supplementation in women restored serum DHEA levels to those of young adults. Interestingly, this result was gender specific and no change was detected in men. Neither gender had changes in basal metabolic rate, bone mineral density, or lipid profiles. No significant adverse effects were observed.
Fig 6. Changes in DHEA, DHEA-S, testosterone, dihydrotestosterone, and androstenedione after 400 mg oral DHEA in a 72 year-old man. DHEA-S, mcg/dl. All others, ng/dl. 14
(click on thumbnail for full sized image) On the other hand, when pharmacologic doses of DHEA are administered (., doses that are far in excess of those required to restore levels to those of healthy young adults), testosterone and DHT levels do increase significantly. For example, in one elderly man, to whom 400 mg of DHEA was administered, significant and rapid rises were noted in DHEA, DHEA-S , testosterone and DHT (Figure 6). 14