Other side effects include increased risk of heart problems in older men with poor mobility, according to a 2009 study at Boston Medical Center. A 2017 study published in JAMA found that treatments increase coronary artery plaque volume. Additionally, the Food and Drug Administration (FDA) requires manufactures to include a notice on the labeling that states taking testosterone treatments can lead to possible increased risk of heart attacks and strokes. The FDA recommends that patients using testosterone should seek medical attention right away if they have these symptoms:
9. CAUTION: Chasteberry (Vitex agnus castus) . Chasteberry has been shown in several in vitro studies to bind to dopamine receptors in pituitary cells.  It also has a history of being used in women for hyperprolactinemia.  Unfortunately, there appear to be no studies on men and, at least in women, it has some unusual affects such as increasing progesterone and LH (leutinizing hormone) while decreasing FSH (follicle stimulating hormone). In my opinion, this seems like an unpredictable mix of effects for long term usage.