Nandrolone mode of action

A Phase III , randomised, 12 month clinical trial (CS21) in prostate cancer [4] compared androgen deprivation with one of two doses of degarelix or the GnRH agonist, leuprolide . Both degarelix doses were at least as effective as leuprolide at suppressing testosterone to castration levels (≤ ng/mL) from Day 28 to study end (Day 364). Testosterone levels were suppressed significantly faster with degarelix than with leuprolide, with degarelix uniformly achieving castration levels by Day 3 of treatment which was not seen in the leuprolide group. There were no testosterone surges with degarelix compared with surges in 81% of those who received leuprolide. Degarelix resulted in a faster reduction in PSA levels compared with leuprolide indicating faster control of the prostate cancer. Recent results also suggest that degarelix therapy may result in longer control of prostate cancer compared with leuprolide. [5]

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The next document issued was a proposed rule dated June 17, 1994, which states, “FDA is issuing a notice of proposed rulemaking in the form of an amended tentative final monograph that would establish conditions under which OTC topical health-care antiseptic drug products are generally recognized as safe and effective and not misbranded. FDA is issuing this notice of proposed rulemaking on topical antimicrobial drug products after considering the public comments on that notice and other information in the administrative record for this rulemaking. FDA is also requesting data and information concerning the safety and effectiveness of topical antimicrobials for use as hand sanitizers or dips.” [70] In the 1994 update to the rule, TCS was effectively removed from the drug category which made it available for use in consumer products. [71]

Nandrolone mode of action

nandrolone mode of action


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